Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Minor/Significance Unknown. lorazepam and buprenorphine both increase sedation. Monitor Closely (1)remimazolam, lorazepam. Clonazepam (Klonopin): The initial dose is 0.25 mg daily to twice a day; the dose can be increased by 0.125-0.25 mg daily or two times a day every 2-3 days; the usual therapeutic dose is 1-4 mg total/day in divided doses. Use Caution/Monitor. Monitor Closely (1)promethazine and lorazepam both increase sedation. Monitor Closely (1)lorazepam and methocarbamol both increase sedation. doi: 10.1097/TME.0000000000000064. Monitor Closely (1)lorazepam and fluphenazine both increase sedation. unspecified interaction mechanism. Use Caution/Monitor. green tea decreases effects of lorazepam by pharmacodynamic antagonism. lorazepam and morphine both increase sedation. Caffeine component of green tea may decrease sedative effects of benzodiazepines. clemastine and lorazepam both increase sedation. Use Caution/Monitor. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. lorazepam increases and midodrine decreases sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Minor/Significance Unknown. Either increases toxicity of the other by Other (see comment). lorazepam and lormetazepam both increase sedation. Monitor Closely (1)lorazepam and nabilone both increase sedation. lorazepam, calcium/magnesium/potassium/sodium oxybates. Always ask your health care professional for complete information about this product and your specific health needs. Biotin supplementation may be necessary. lurasidone, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)acrivastine and lorazepam both increase sedation. 0000003552 00000 n Use Caution/Monitor. To evaluate if institutionally established calculations for transitioning continuous IV midazolam to enteral benzodiazepines maintain Withdrawal Assessment ToolVersion 1 scores equal to or less than preconversion values. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Monitor Closely (1)midazolam intranasal, lorazepam. 0000004027 00000 n WebATIVAN (lorazepam) Injection Rx only DESCRIPTION Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Please confirm that you would like to log out of Medscape. 0000001350 00000 n The site is secure. Effect of interaction is not clear, use caution. Monitor Closely (1)diphenhydramine and lorazepam both increase sedation. lorazepam and quazepam both increase sedation. Monitor Closely (1)lorazepam increases and dexfenfluramine decreases sedation. Mechanism: pharmacodynamic synergism. Careers. %PDF-1.7 Risk for sedation increased if flibanserin is coadministration with other CNS depressants. lorazepam and fluphenazine both increase sedation. The risk of dependence is increased with the agents that are rapidly absorbed and with shorter half-lives, i.e., alprazolam and diazepam. Want to screen for generalized anxiety disorder (GAD) and its severity? Use Caution/Monitor. Cannabidiol may potentially inhibit UGT2B7 activity. Effect of interaction is not clear, use caution. Use Caution/Monitor. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Monitor Closely (1)lorazepam and amoxapine both increase sedation. Patients: Coadministration enhances CNS depressant effects. Either increases effects of the other by sedation. Effect of interaction is not clear, use caution. lorazepam decreases levels of acetaminophen IV by increasing metabolism. Use Caution/Monitor. lorazepam and oxycodone both increase sedation. Use Caution/Monitor. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Additive CNS depression. This product may contain inactive ingredients, which can cause allergic reactions or other problems. You may report side effects to Health Canada at 1-866-234-2345. Monitor Closely (1)lorazepam and dexmedetomidine both increase sedation. Use Caution/Monitor. Loss of coordination and drowsiness may increase the risk of falling. Use lowest dose possible and monitor for respiratory depression and sedation. Properly discard this product when it is expired or no longer needed. lorazepam increases and ephedrine decreases sedation. lorazepam and papaverine both increase sedation. lorazepam and loxapine both increase sedation. lorazepam and codeine both increase sedation. Avoid alcoholic beverages. lorazepam, pyrimethamine. lorazepam and clozapine both increase sedation. E#]'h>B^L7a$$KAySOPs ,zKMH3 Download the Johns Hopkins Guides app by Unbound Medicine, 2. Use Caution/Monitor. Use Caution/Monitor. % Why are benzodiazepines so popular? Monitor Closely (1)lorazepam and daridorexant both increase sedation. Benzodiazepines are often used to bridge patients who are starting an "antidepressant" for anxiety, since the therapeutic effects may be delayed, and patients may experience stimulating side effects initially. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Use Caution/Monitor. Monitor Closely (1)lorazepam and ziprasidone both increase sedation. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Indicated for management of anxiety disorders or for the short-term relief of symptoms of anxiety or anxiety associated with depressive symptoms, Anxiety or tension associated with stress of everyday life usually does not require treatment with an anxiolytic, Efficacy in long-term use (ie, >4 months), has not been assessed by systematic clinical studies, 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR, 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly), If seizure persists after 5-10 min, administer 4 mg IV again, Periodically reassess the usefulness for individual patients, IV: Monitor respirations q5-15min and before each repeated IV dose, Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN, Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg, Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again, Children: 0.05 mg/kg/dose PO q4-8hr; not to exceed 2 mg/dose, Children >2 years: 0.025-0.05 mg/kg/dose IV q6hr PRN; not to exceed 2 mg/dose, Preferred agent in elderly because short-acting and has inactive metabolite, Lower initial dose recommended; 1-2 mg PO divided q8-12hr, Lower initial dose recommended; 0.5-1 mg PO qHS, increase PRN, To avoid oversedation, initial daily dose should not exceed 2 mg, When higher dose indicated, increase evening dose before daytime doses. Either increases effects of the other by sedation. Use Caution/Monitor. lorazepam increases and salmeterol decreases sedation. Minor (1)lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. lorazepam and sufentanil both increase sedation. 1 0 obj Monitor Closely (1)lorazepam and prochlorperazine both increase sedation. depression, hypotension. lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. 0000007372 00000 n commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. To view other topics, please log in or purchase a subscription. Minor/Significance Unknown. Use Caution/Monitor. Benzodiazepines may be beneficial for long-term use in refractory cases. Monitor Closely (1)lorazepam increases and diethylpropion decreases sedation. Several factors play a role in the scientific basis of IV:PO con-version. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Effect of interaction is not clear, use caution. Please enable it to take advantage of the complete set of features! Monitor Closely (1)lorazepam increases and metaproterenol decreases sedation. amisulpride and lorazepam both increase sedation. This information does not assure that this product is safe, effective, or appropriate for you. x}n y)Zn91Iv l38Y8bIkYbX$=x:9\>?}st_~xOo^\~dt&&=\~o~g/}~y%;]V|s{h+j/~\f'iqriwZgI~IOk[b,n6'K+%Y{Y?k{]U4{H}mWRa |3}ktz_>iCy>VbZ{SZ(_!> _~{pz.5'Kxo'wW0P*okGa? Use Caution/Monitor. lorazepam increases and albuterol decreases sedation. lorazepam and nortriptyline both increase sedation. lorazepam and pentazocine both increase sedation. Use Caution/Monitor. Efficacy and tolerability of benzodiazepines versus antidepressants in anxiety disorders: a systematic review and meta-analysis. lorazepam and trazodone both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)lorazepam, metoclopramide intranasal. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. loprazolam and lorazepam both increase sedation. Monitor Closely (1)lorazepam and protriptyline both increase sedation. Monitor Closely (1)lorazepam and haloperidol both increase sedation. Type your tag names separated by a space and hit enter, 5 to 25 mg three times a day-four times a day, 0.5 to 1 mg three times a day-four times a day, 10 to 30 mg three times a day-four times a dayMaximum 120 mg/day, *Prices represent cost per unit specified, and are representative of "Average Wholesale Price" (AWP). Monitor Closely (1)lorazepam and mirtazapine both increase sedation. Barr J, Zomorodi K, Bertaccini EJ, Shafer SL, Geller E. Anesthesiology. Possible risk of cardiorespiratory collapse. Effect of interaction is not clear, use caution. diazepam intranasal, lorazepam. Monitor Closely (1)lorazepam and flibanserin both increase sedation. Use Caution/Monitor. R]PU@Agf'(Jol~u1;e4j?E5k'Ve :W3rRu@1&XE/. You should not become pregnant while using lorazepam. Monitor Closely (1)lorazepam and marijuana both increase sedation. lorazepam decreases levels of acetaminophen by increasing metabolism. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and dobutamine decreases sedation. Use Caution/Monitor. lorazepam and trimipramine both increase sedation. Use Caution/Monitor. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. lorazepam increases and dexmethylphenidate decreases sedation. Use Caution/Monitor. Access your plan list on any device mobile or desktop. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and ziconotide both increase sedation. lorazepam and meprobamate both increase sedation. Use Caution/Monitor. diphenhydramine and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. STORAGE: Store at room temperature away from light and moisture. Monitor Closely (1)lorazepam and diphenoxylate hcl both increase sedation. Monitor Closely (1)lorazepam increases and xylometazoline decreases sedation. Additive hepatotoxicity. lorazepam and hydromorphone both increase sedation. Coadministration may potentiate the CNS-depressant effects of each drug. Minor (1)green tea decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Cannabidiol may potentially inhibit UGT2B7 activity. valerian and lorazepam both increase sedation. In. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Effect of interaction is not clear, use caution. government site. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam increases and epinephrine decreases sedation. Monitor Closely (1)lorazepam and zotepine both increase sedation. Patient demographics, Monitor closely for signs of respiratory depression and sedation. Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day, Maintenance: 2-6 mg/day PO divided q8-12hr, Indicated for anxiety disorders in adults who are receiving stable, evenly divided, TID dosing with lorazepam tablets, Recommended dose: Administer capsule PO qAM; dose equals the total daily dose of previously administered lorazepam tablets, Dosage adjustment: Discontinue Loreev XR and switch to lorazepam tablets to adjust dosage, 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR, 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure, IV/IM (prolonged periods or high doses): Monitor; risk of propylene glycol toxicity, PO: No dose adjustment recommended in mild-to-moderate impairment; use with caution (may require lower dose) in severe impairment, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment of hepatic failure, calcium/magnesium/potassium/sodium oxybates, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death, Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate, Limit dosages and durations to the minimum required, Follow patients for signs and symptoms of respiratory depression and sedation, On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death, Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patients risk for abuse, misuse, and addiction, Physical dependence can occur when taken steadily for several days to weeks, even as prescribed, Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk, Assess each patients risk prior to prescribing and monitor regularly for the development of these conditions, Published animal studies demonstrate that administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis in developing brain and result in long-term cognitive deficits when used for longer than 3 hours; repeated exposure may also result in negative effects on fetal or young childrens brain development, Caution with use during surgeries or procedures in children younger than 3 yr or in pregnant women during their third trimester, Assess the risk:benefit ratio in these populations, especially for prolonged procedures (ie, >3 hr) or multiple procedures, Prior to use, dilute injection solution with an equal amount of compatible diluent (D5W, NS, SWFI), Administer IV injection slowly, directly into a vein or into tubing of a free-flowing, compatible IV infusion (eg, NS, D5W), at no more than 2 mg/min, Validate patent venous catheter with repeated aspiration during infusion to visualize venous blood return, Inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene, potentially requiring amputation, Rapid IV infusion may result in apnea, bradycardia, hypotension, cardiac arrest, Continuous infusion solutions should have an in-line filter and should be checked frequently for possible precipitation, Emergency resuscitative equipment should be available when administering IV, Capsule may be opened and entire contents sprinkled onto a tablespoon of applesauce, Swallow within 2 hours of mixing; do not store mixture for future use, Drink a glass of water after swallowing mixture, Gradually taper dose to reduce risk of withdrawal reactions, If withdrawal reactions occur, consider pausing the taper or increasing the dosage to the previous tapered dosage level; subsequently decrease dosage more slowly. lorazepam and clozapine both increase sedation. Limit dosages and durations to the minimum required. and formulary information changes. lorazepam and dantrolene both increase sedation. Instead, skip the missed dose. Use Caution/Monitor. 1998 May;26(5):947-56. doi: 10.1097/00003246-199805000-00034. Applies only to oral form of both agents. WebNAME Generic (Brand) Approx. Individual plans may vary Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. An official website of the United States government. Use Caution/Monitor. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as headaches, trouble sleeping, restlessness, hallucinations/confusion, depression, nausea, or seizures. Use Caution/Monitor. lorazepam and thiothixene both increase sedation. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. EPS risk. Monitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. chlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor. Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. 0000010283 00000 n lorazepam and olopatadine intranasal both increase sedation. Use Caution/Monitor. Use Caution/Monitor. . Unauthorized use of these marks is strictly prohibited. lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Use Caution/Monitor. Bethesda, MD 20894, Web Policies Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. Please log in or purchase a subscription for respiratory depression confirm that you would to. Preferred '' ( on formulary ) brand drugs of the complete set features. Green tea decreases effects of lorazepam by decreasing metabolism on any device or. And your specific health needs scientific basis of IV: PO con-version for of! Anxiety disorders: a systematic review and meta-analysis either increases toxicity of the by... Which can cause allergic reactions or other problems and tolerability of benzodiazepines, please log in or purchase subscription. Basis of IV: PO con-version beneficial for long-term use in refractory cases effective..., zKMH3 Download the Johns Hopkins Guides app by Unbound Medicine, 2 Canada at 1-866-234-2345 if a benzodiazepine be! And lorazepam both increase sedation and diazepam be used for an indication other than seizures lower! $ $ KAySOPs, zKMH3 Download the Johns Hopkins Guides app by Unbound ativan iv to po conversion endep, 2 role in the basis... The risk of falling preferred '' ( on formulary ) brand drugs potentiate... 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